Almost 14 months after his no hitter against Chicago, Francisco Liriano (2-7) got his second straight win, giving up just one run in seven innings on four hits. He struck out five.
Youkilis went 1-for-4 in his White Sox debut, with a single in the eighth. Chicago's lone run came in the seventh inning off an Alexei Ramirez sac fly. Trevor Plouffe's sac fly in the seventh made it 4-1 and that's how it would stay.
Jake Peavy (6-4) took the loss, giving up 10 hits and three earned runs in six innings. He struck out seven.
Jared Burton recorded his second save of the season.
Game 2 of the series is Tuesday at 7:10 p.m. CT.
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