Francisco Liriano worked into the seventh inning for the first time, pitching six and two-thirds innings and giving up only four hits and one earned run. He had six strikeouts.
The Twins retook the lead for good in the eighth on a solo home run from Josh Willingham, his 14th of the season.
Glen Perkins got his first save of the year and third of his career for Minnesota. Regular closer Matt Capps is out with shoulder inflammation.
The third game of the series is Thursday at 7:05 p.m. ET.