The anticipated matchup between Griffin and Minnesota's Kevin Love was one- sided, with the rookie dominating in the opening half to give the Clips a double-digit cushion they never relinquished.
Griffin pulled down eight rebounds, ending his run of double-doubles at 27, and the backcourt combination of Eric Gordon and Baron Davis carried Los Angeles in the second half for its sixth win in seven games.
Gordon, who suffered a ligament injury to his right ring finger in the first quarter, netted 18 of his 23 points in the final 24 minutes, while Davis added 20 points in the lopsided win.
Love put up most of his stats when the game was out of reach, logging 26 points and 11 rebounds in the loss, Minnesota's third straight and eighth in nine games. The Timberwolves shot 1-for-16 from three-point range.