The White Sox took advantage two walks and a single in the first inning, with Alex Rios hitting a one-out Grand Slam to give Chicago a 4-0 lead. Walters would rebound and hold on through the sixth inning when Rios would hit another two-run home run and chase the Twins starter after 5.0 innings.
The Twins would get on the board in the top of the third with a sacrifice fly by Eduardo Escobar and again in the ninth when Matt Carson's sacrifice scored Ryan Doumit. It would not be enough, however, with the Twins scoring just two runs on eight hits in the game.
Alex Burnett, Brian Duensing and Jared Burton combined for three scoreless innings out of the bullpen. Ryan Doumit and Chris Parmalee were both 2-for-4 in the game.
The Twins lost two of three to the White Sox and have Thursday off before welcoming the Cleveland Indians to town for ten-game home stand over the next two weeks.