The win ended Minnesota's season while propelling Green Bay into the second round of the playoffs, where the Packers will play the San Francisco 49ers next weekend.
Ponder was inactive for the game as he struggled with an elbow injury all week. Joe Webb started his first game of the season in place of Ponder and was 11-of-30 passing for 180 yards with one touchdown and one interception.
The Vikings jumped out to a 3-0 lead on their first possession of the game but the Packers scored 24 unanswered points to secure the blowout win.
Adrian Peterson carried the ball 22 times for 99 yards in the game.
Aaron Rodgers was 23-of-33 passing for 274 yards and one touchdown while DuJuan Harris led the Packers' rushing attack with 17 carries for 47 yards and one touchdown.